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Depression is connected to the improper functioning of neural pathways that connect parts of the brain responsible for processing emotional information. Some of these networks may also be responsible for sensing physical pain. As a result, chronic pain of any kind tends to grow worse in depressed people. They may suffer from regular headaches and back pain, along with chest pain and muscle aches. Sleep disruption is common along with fatigue and exhaustion. Digestive problems like nausea and indigestion may also be experienced. Change in breathing pattern, insomnia, and change in weight may be some other effects.