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Depression may affect people of all age groups. And most of the time the reason why people get depressed remains unexplained. However, some of the leading causes of depression include: • Genetic and Biological Factors: Depression has been linked to genetics. Having siblings or parents with depression may be a risk factor. • Imbalance in Brain Chemistry: Imbalance in the brain’s neurotransmitters may cause depression. When some neurotransmitters are in short supply, it results in symptoms associated with clinical depression. • Female Sex Hormones: Women are more prone to depression than men due to hormonal risk factors. • Circadian Rhythm Disturbance: When the normal circadian rhythm of the body gets disrupted, it leads to seasonal affective disorder. • Poor Nutrition: Depression may stem from poor dietary habits, especially minerals and vitamin deficiencies. • Physical Health Issues: Any problems in your physical health may translate to mental health issues as well. • Substance Abuse: Alcohol and drugs often contribute to depression. • Stressful Life Events: When a person goes through a traumatic event that exceeds his/her ability to cope, it could result in depression. • Grief and Loss: Many grieving individuals start showing signs of depression after the loss of a loved one.