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Although depression affects patients both mentally and emotionally, it is accompanied by physical side effects as well. These include: • Pain: Depressed individuals often complain about vague pains and aches, especially in their back, limbs, and joints. Both the pain and mood problems stem from dysregulation of the neurotransmitters, norepinephrine and serotonin. • Gastrointestinal Issues: Depression patients may experience stomach problems like constipation or diarrhea. • Fatigue: Depressed people may feel ill-rested no matter how long they sleep. They find it hard to leave the bed in the morning and even the simplest of chores like bathing seem bothersome. • Mood swings, loss of interest, and sleep issues may also be experienced.